Case for Supporting Astrocyte Energetics in Glucose Transporter 1 Deficiency Syndrome

Blog Science

Dr. Karin Borges from the University of Queensland in Australia recently published a manuscript, the title is: “Case for supporting astrocyte energetics in glucose transporter 1 deficiency syndrome”.

Dr. Borges kindly provided a summary of her manuscript to share with our community. Please see the summary below:

New Evidence for Optimized Treatment of Glut1 Deficiency Syndrome: Add-on Medium Chain Triglycerides

Glut1 Deficiency Syndrome (Glut1DS) is a rare condition where the brain doesn’t get enough glucose due to faulty glucose transport at the blood-brain barrier. This shortage can lead to seizures and other neurological issues. Ketogenic diets, which increase ketone bodies as an alternative energy source, are currently the first-line treatment. These ketone bodies are mainly used by neurons for energy.

However, new research from scientists located at the University of Queensland indicates that astrocytes, another important type of brain cells, also suffer from glucose shortages in Glut1DS. Astrocytes support neurons and are essential for brain health. When they lack glucose, neuron function is negatively impacted, which can lead to seizures.

The scientists provided evidence that adding medium chain triglycerides (MCTs) to the ketogenic diet will address this issue. MCTs provide medium chain fatty acids (MCFAs), which astrocytes can use for energy.  MCFAs also help produce crucial neurotransmitters to reduce harmful brain activity.

Researchers recommend further studies to find the optimal MCT doses and to monitor their long-term effects, aiming to improve treatment outcomes for Glut1DS patients. This new approach provides a more comprehensive solution to the energy shortages in the brain caused by Glut1DS.

I want to thank Dr. Borges for her continued work to help our community and for sharing this summary.

Thank you for reading this post and please send me any questions or comments to [email protected].